alpha {coin}R Documentation

Genetic Components of Alcoholism

Description

Levels of expressed alpha synuclein mRNA in three groups of allele lengths of NACP-REP1.

Usage

data("alpha")

Format

A data frame with 97 observations on the following 2 variables.

alength

allele length, a factor with levels short, intermediate and long.

elevel

expression levels of alpha synuclein mRNA.

Details

Various studies have linked alcohol dependence phenotypes to chromosome 4. One candidate gene is NACP (non-amyloid component of plaques), coding for alpha synuclein. B\"onsch et al. (2005) found longer alleles of NACP-REP1 in alcohol-dependent patients compared with healthy controls and report that the allele lengths show some association with levels of expressed alpha synuclein mRNA.

Source

Dominikus B\"onsch, Thomas Lederer, Udo Reulbach, Torsten Hothorn, Johannes Kornhuber \& Stefan Bleich (2005). Joint Analysis of the NACP-REP1 Marker Within the Alpha Synuclein Gene Concludes Association with Alcohol Dependence. Human Molecular Genetics, 14(7), 967–971.

Torsten Hothorn, Kurt Hornik, Mark A. van de Wiel \& Achim Zeileis (2006). A Lego system for conditional inference, The American Statistician, 60(3), 257–263.

Examples


  boxplot(elevel ~ alength, data = alpha)
  kruskal_test(elevel ~ alength, data = alpha)


[Package coin version 1.0-24 Index]