Package: PFIM
Type: Package
Title: Population Fisher Information Matrix
Version: 7.0.3
Date: 2026-04-09
Authors@R: c(
    person(given = "Romain",
           family = "Leroux",
           role = c("aut","cre"),
           comment = c(ORCID = "0009-0009-5779-5303"),
           email = "romainlerouxPFIM@gmail.com"),
    person(given = "France",
           family = "Mentr\u00E9",
           role = c("aut"),
           comment = c(ORCID = "0000-0002-7045-1275"),
           email = "france.mentre@inserm.fr"),
    person(given = "J\u00E9r\u00E9my",
           family = "Seurat",
           role = c("ctb"),
           email = "jeremy.seurat@inserm.fr"))    
Maintainer: Romain Leroux <romainlerouxPFIM@gmail.com>
NeedsCompilation: no
Description: Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to 
    Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
    Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
    Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
    Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
    Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
    Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.
URL: http://www.pfim.biostat.fr/, https://github.com/packagePFIM
BugReports: https://github.com/packagePFIM/PFIM/issues
Depends: R (>= 4.0.0)
License: GPL (>= 3)
Encoding: UTF-8
VignetteBuilder: knitr
Imports: utils, inline, Deriv, methods, deSolve, purrr, stringr, S7,
        Matrix, ggplot2, Rcpp, RcppArmadillo, pracma, kableExtra,
        tibble, scales, knitr
Collate: 'Administration.R' 'AdministrationConstraints.R' 'Fim.R'
        'PFIMProject.R' 'Optimization.R' 'PGBOAlgorithm.R'
        'PSOAlgorithm.R' 'SimplexAlgorithm.R' 'FedorovWynnAlgorithm.R'
        'MultiplicativeAlgorithm.R' 'Model.R' 'Arm.R' 'BayesianFim.R'
        'ModelError.R' 'Combined1.R' 'Constant.R' 'Design.R'
        'Distribution.R' 'Evaluation.R' 'IndividualFim.R'
        'LibraryOfModels.R' 'LibraryOfPDModels.R' 'LibraryOfPKModels.R'
        'LogNormal.R' 'ModelODE.R' 'ModelAnalytic.R' 'ModelInfusion.R'
        'ModelAnalyticInfusion.R' 'ModelAnalyticInfusionSteadyState.R'
        'ModelAnalyticSteadyState.R' 'ModelODEBolus.R'
        'ModelODEDoseInEquations.R' 'ModelODEDoseNotInEquations.R'
        'ModelODEInfusion.R' 'ModelODEInfusionDoseInEquation.R'
        'ModelParameter.R' 'Normal.R' 'PFIM-package.R'
        'PopulationFim.R' 'Proportional.R' 'SamplingTimeConstraints.R'
        'SamplingTimes.R' 'plotMethods.R' 'utils.R' 'zzz.R'
RoxygenNote: 7.3.3
Suggests: rmarkdown, testthat (>= 3.0.0)
Packaged: 2026-04-09 09:05:28 UTC; a.romain.leroux
Author: Romain Leroux [aut, cre] (ORCID:
    <https://orcid.org/0009-0009-5779-5303>),
  France Mentré [aut] (ORCID: <https://orcid.org/0000-0002-7045-1275>),
  Jérémy Seurat [ctb]
Repository: CRAN
Date/Publication: 2026-04-09 09:30:22 UTC
Built: R 4.6.0; ; 2026-05-11 03:34:21 UTC; windows
